What is a potential psychological effect of ketamine?

Ketamine has a range of psychological effects, one of which can include paranoia. This experience may arise due to the drug's dissociative properties, causing alterations in perception and a disconnection from reality that can sometimes lead individuals to feel suspicious or fearful. While some users may describe feeling euphoric or a sense of confidence, it is essential to recognize that these positive sensations are often accompanied by negative psychological experiences, especially in higher doses or in susceptible individuals.

In contrast, while increased anxiety, a confidence boost, and heightened awareness can occur with substance use, they are typically not the primary psychological effects associated with ketamine. The nature of ketamine's action on glutamate neurotransmission in the brain can lead to complex emotional and psychological states, frequently contributing more toward feelings of paranoia in certain contexts. Understanding this potential effect can be crucial for clinicians in monitoring clients' responses to ketamine, especially in therapeutic settings.